“Artificial Mitochondria Transfer (AMT) in Ex Vivo Porcine Model of DCD Renal Transplantation” – Keynote Paper at the 2022 American Transplant Congress in Boston, MA

BioMedInnovation (BMI) announces its collaboration and support of a distinguished international team led by Dr. Giuseppe Orlando involving a Keynote presentation – “Artificial Mitochondria Transfer (AMT) to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation” –at the 2022 American Transplant Congress in Boston, MA.

Chip Aardema, BMI’s Head of Perfusion, collaborated with a team of surgeons and physicians from the United States and Italy to deliver the study undertaken at Wake Forest Institute of Regenerative Medicine (WFIRM), Winston Salem, NC.

The study explored whether artificial mitochondria transfer mitigates renal injury in an in vitro model of tubular damage and an ex vivo porcine model of transplantation of circulatory death kidney using BMI’s proven CaVESWave® organ and tissue perfusion platform.

Chip Aardema said, “the team at BMI was delighted to play our part and that our CaVESWave® platform enabled an American-Italian team to deliver a groundbreaking study that concluded that Artificial Mitochondria Transfer mitigates damage both in vitro and ex vivo.”

Keeping more paths to transplant open.

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Blood-free perfusate

Proprietary acellular perfusate designed to support metabolically active preservation—enabling oxygen delivery, nutrient support, and management of oxidative stress without the need for donor-matched blood.

Real-time visibility across the journey

Tracks organ status and location during preservation and transport, supporting coordination and assessment across teams.

Portable perfusion. Continuous preservation.

Automated, portable device designed to maintain kidneys in a metabolically active state during preservation and transport.
Operates at room temperature without donor-matched blood.