Ex-vivo Pharmacodynamic Research Platform

Ex-Vivo Institute offers expert biostatisticians and statistical programmers to craft detailed study plans (including precise definitions of endpoints and descriptions of analyses), address regulatory risks, and maximize success from the outset.

Examples of services provided include:

  • Organ and tissue preservation models
  • Broad preservation temperature ranges (2–37°C)
  • Therapeutic intervention access
  • Biomarker sampling support
  • Customizable pressure and waveform control
  • Optional dialysis loop integration
  • Leasing and research support programs

Background

BMI OrganBank® has developed its technology and capabilities in North Carolina’s world renowned research triangle, by serving and collaborating with leading institutions like Duke University’s ex vivo organ laboratory “DEVOL”, Wake Medical’s “WFIRM”, and UNC Chapel Hill’s Kidney Center.

Our patented technology has been deployed to support leading clinicians, researchers and organ specialists to perfuse and preserve an array of organs, and tissue, including animal and human kidney, lung, liver, small intestine, and vascularized composite allografts (VCAs) to allow vital therapies and clinical methodologies to be advanced.

BMI OrganBank’s laboratory platform, OrganBank Lab, has CardioVascular Emulation technology at its core, known as CaVESWave®, and is currently serving Duke, Yale University’s Neuroscience Lab, WFIRM, Porter Adventist, Colorado, with a number of new deployments in the mobilization.

OrganBank Lab was considered the appropriate platform on which to perfuse human lungs to allow vital gene therapy to be advanced into debilitating disease impacting the respiratory system.

Similarly the platform has allowed research into the effects on vascular flow ex vivo of a new drug therapy on NonAlcoholic Steatohepatitis (NASH).

To further demonstrate its versatility, the OrganBank Lab platform is assisting studies on behalf of the Department of Defense into the opportunity to undertake lower intestine transplants and vascularized composite allografts that could transform the lives of our horrifically injured servicemen and women and their families, not least leading to an effective Battlefield Recovery System™ (“BRS”).​

BMI’s home laboratory in the First Flight Venture Center™ of the North Carolina Research Triangle Park will soon host research projects for clients in the BioPharma arena and our vision is to see this capability expanded to other geographies to serve our clients growing need.

During the COVID-19 pandemic era it has become evident that BioPharma professionals must find ways to expedite research programs in a way that allows them to fail early and succeed more quickly and cost-effectively.

Integrated Analytical & Study Support

The Ex Vivo Institute supports translational research through biomarker analysis, study design collaboration, biostatistics, and computational approaches designed to maximize physiologic insight and research value.

Research & Clinical Collaborators

Publications

Kidney

  1. Transplantation Direct
    Subnormothermic Oxygenated Machine Perfusion (24h) in DCD Kidney Transplantation
    Abraham N, et al.

  2. Annals of Surgery
    Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation

  3. Transplantation Journal
    Renal Extracellular Matrix Scaffolds from Discarded Kidneys Maintain Glomerular Morphometry and Vascular Resilience and Retain Critical Growth Factors

  4. Nature Biomedical Engineering
    Evolving Adeno-Associated Viruses for Gene Transfer to the Kidney via Cross-Species Cycling of Capsid Libraries
    Rosales A, et al. (2025)

  5. American Journal of Transplantation
    24h OrganBank Decreases DGF Compared to LifePort in Porcine 30min DCD Kidney Auto-Transplantation
    Abraham N, et al. (2026)

  6. American Journal of Transplantation
    OrganBank End-to-End Bloodless 20°C Kidney O₂ Perfusion Eliminates DGF Compared to LifePort
    Abraham N, et al. (2026)


Eye

  1. Investigative Ophthalmology & Visual Science
    Portable Ex Vivo Whole Eye Preservation System: Optimization and Validation in a Porcine Model
    Kopparthy V, et al. (2026)

  2. Transplantation
    Ex Vivo Whole Eye Perfusion System
    Adcock T, et al. (2026)


Liver

  1. Frontiers in Medicine
    Two Compartment Evaluation of Liver Grafts During Acellular Room Temperature Machine Perfusion (acRTMP) in a Rat Liver Transplant Model

  2. Clinical and Translational Discovery
    The Effect of Obeticholic Acid on Hepatic Blood Flow in Isolated, Perfused Porcine Liver

  3. International Journal of Transplantation
    Validation of Cardio-Emulation Pump Perfused, Porcine Liver Model: Blood Flow Response to Temperature


Whole Body / Multi-Organ / Systemic Recovery

  1. Nature
    Cellular Recovery After Prolonged Warm Ischemia of the Whole Body

  2. Nature
    Improved Organ Recovery After Oxygen Deprivation

  3. NIH
    Restoring Cell and Organ Function After the Heart Stops

  4. Scientific American
    How Scientists Revived Dead Pigs’ Organs, and What the Feat Means for Transplants

Lung

  1. JTCVS Techniques
    Dual Ex Vivo Lung Perfusion via Pulmonary and Bronchial Arteries in a Porcine Model
    Nakata K, et al. (2025)


Limbs / VCA

  1. Transplantation
    Human Limb Preservation Using Oxygenated Machine Perfusion with Hemoglobin-Based Oxygen Carriers Modulates Hypoxia and Immune Injury Pathways
    Kopparthy V, et al. (2026)

  2. American Journal of Transplantation 
    Perfluorocarbon Nanoemulsions for Simultaneous Delivery of Oxygen and Antioxidants During Machine Perfusion Supported Organ Preservation
    Janjic JM, et al. (2024)


Brain / CNS

  1. Nature
    Restoration of Brain Circulation and Cellular Functions Hours Post-Mortem


Cross-Organ / Technology Development

  1. Reconstructive Transplantation and Regenerative Surgery
    Preservation Technologies in Organ Transplantation
    Cohen E, Copus J, Kopparthy V

  2. Pharmaceutics
    Perfluorocarbon Nanoemulsions for Simultaneous Delivery of Oxygen and Antioxidants During Machine Perfusion Supported Organ Preservation
    Patel, Smith, et al. (2026)

Keeping more paths to transplant open.

PLATFORM & TECHNOLOGY

  • Platform Overview
  • Clinical Workflow
  • The Science
  • System Components

RESEARCH SERVICES

  • Ex-Vivo Institute
  • OrganBank Lab

CLINICAL EVIDENCE

  • Publications
  • Preclinical Validation
  • Data & Outcomes
  • Scientific Posters & Presentations

ABOUT

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  • Contact

NEWS & INSIGHTS

  • Company News
  • Featured Content
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Wake Forest Institute of Regenerative Medicine
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Blood-free perfusate

Proprietary acellular perfusate designed to support metabolically active preservation—enabling oxygen delivery, nutrient support, and management of oxidative stress without the need for donor-matched blood.

Real-time visibility across the journey

Tracks organ status and location during preservation and transport, supporting coordination and assessment across teams.

Portable perfusion. Continuous preservation.

Automated, portable device designed to maintain kidneys in a metabolically active state during preservation and transport.
Operates at room temperature without donor-matched blood.