Research Services – BMI OrganBank

Translational Research Infrastructure

Advanced ex vivo and in vivo research capabilities designed to support organ preservation science, therapeutic development, biomarker discovery, and translational medicine.

Research Capabilities

Advancing Translational Research Through Ex Vivo Science

The Ex Vivo Institute supports organ preservation studies, therapeutic evaluation, biomarker analysis, and preclinical research through advanced ex vivo and in vivo capabilities.

Ex Vivo Organ Studies

Advanced preservation and therapeutic evaluation in ex vivo organ models.

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Biomarker & Assay Services

Laboratory analysis supporting biomarker discovery and translational research.

Translational Informatics

Data-driven analysis and computational approaches for translational medicine.

Preclinical Support

Customized ex vivo and in vivo research services for therapeutic development.

Ex-vivo Pharmacodynamic Research Platform

Learn More About OrganBank Lab

Examples of services provided include:

Organ and tissue preservation models
Broad preservation temperature ranges (2–37°C)
Therapeutic intervention access
Biomarker sampling support
Customizable pressure and waveform control
Optional dialysis loop integration
Leasing and research support programs

Ex Vivo Institute offers expert biostatisticians and statistical programmers to craft detailed study plans (including precise definitions of endpoints and descriptions of analyses), address regulatory risks, and maximize success from the outset.

Integrated Analytical & Study Support

The Ex Vivo Institute supports translational research through biomarker analysis, study design collaboration, biostatistics, and computational approaches designed to maximize physiologic insight and research value.

Scientific Leadership

Researchers, clinicians, and industry leaders with expertise spanning transplantation, organ preservation, medical technology, and translational research.

Carrie DiMarzio

Chief Executive Officer

David Gerber

Chief Medical Officer

Varun Kopparthy

Chief Technology Officer - VCA

Chip Aardema

Head Of Perfusion

Research & Clinical Collaborators

Transplant surgeons and researchers at leading academic medical centers, advancing the science behind organ preservation.

Duke Ex Vivo Organ Lab

What we're building together: BMI's room-temperature preservation science, including the OrganBank Kidney (OBK) platform and the DEVOL perfusion solution, was developed in partnership with Duke University.

Andrew Barbas, MD

Chief Scientific Advisor, Abdominal.

Co-Director, Duke Ex Vivo Organ Lab; Abdominal Transplant Surgeon.

Nader Abraham, MD

Co-inventor

Duke University.

Winston-Salem, North Carolina

What we're building together: xxx

Anthony Atala, MD

Scientific Advisor

Tissue Engineering, Regenerative Medicine.

Vijay Gorantla, MD, PhD

Chief Scientific Advisor, VCA

Regenerative Medicine, Organ Transplantation.

UNC Kidney Center

What we're building together: xxx

Prabir Roy-Chaudhury, MD

Scientific Advisor

Nephrologist; Co-Director, UNC Kidney Center. Immediate Past President, American Society of Nephrology.

What we're building together: xxx

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What we're building together: xxx

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References

Selected Publications

American Journal of Transplantation

OrganBank End-to-End Bloodless 20°C Kidney O2 Perfusion Eliminates DGF Compared to Lifeport

American Journal of Transplantation

24h OrganBank decreases DGF compared to LifePort in porcine 30min DCD kidney auto-transplantation

Nature Biomedical Engineering

Evolving Adeno-Associated Viruses for Gene Transfer to the Kidney Via Cross-Species Cycling of Capsid Libraries

Transplantation Direct

Subnormothermic Oxygenated Machine Perfusion (24 h) in DCD Kidney Transplantation

Annals of Surgery

Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation

Frontiers in Medicine Journal

Two Compartment Evaluation of Liver Grafts During Acellular Room Temperature Machine Perfusion (acRTMP) in a Rat Liver Transplant Models

National Institute of Health

Restoring Cell and Organ Function After the Heart Stops

Scientific American

How Scientists Revived Dead Pigs’ Organs, and What the Feat Means for Transplants

Nature Reviews Nephrology

Cellular Recovery After Prolonged Warm Ischaemia

Nature

Improved Organ Recovery After Oxygen Deprivation

Nature

Cellular Recovery After Prolonged Warm Ischaemia of the Whole Body

Clinical and Translational Discover

The Effect of Obeticholic Acid on Hepatic Blood Flow in Isolated, Perfused Porcine Liver: Correction of Oxygen-Nutrient Mismatch Might be a Putative Mechanism of Action in NASH

International Journal of Transplantation

Validation of Cardio-Emulation Pump Perfused, Porcine Liver Model: Blood Flow Response to Temperature

Nature

Restoration of Brain Circulation and Cellular Functions Hours Post-Mortem

Transplantation Journal

Renal Extracellular Matrix Scaffolds From Discarded Kidneys Maintain Glomerular Morphometry and Vascular Resilience and Retains Critical Growth Factors

Keeping more paths to transplant open.

PLATFORM & TECHNOLOGY

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RESEARCH SERVICES

Ex-Vivo Institute
OrganBank Lab

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